| Date | Location | Result | |
| 11/20/10 | Greencastle, Indiana | Trine University 45, DePauw University 35 | Box score |
| 11/13/10 | Crawfordsville, IN | Wabash 47, DePauw University 0 | Box score |
| 11/6/10 | Greencastle, Indiana | DePauw University 30, Austin College 20 | Box score |
| 10/30/10 | Greencastle, Indiana | DePauw University 30, Birmingham-Southern 23 | Box score |
| Oct 23, 2010 | San Antonio, Texas | DePauw University 32, Trinity University 31 | Box score |
| Oct 16, 2010 | Greencastle, Ind. | DePauw University 23, Adrian College 19 | Box score |
| Oct 09, 2010 | Greencastle, Indiana | DePauw University 42, Rhodes College 18 | Box score |
| Oct 02, 2010 | Jackson, Miss. | DePauw University 35, Millsaps College 21 | Box score |
| Sep 25, 2010 | Greencastle, Indiana | DePauw University 35, Sewanee 7 | Box score |
| Sep 18, 2010 | Danville, Ky. | DePauw University 21, Centre College 16 | Box score |
| 09-11-10 | Greencastle, Ind. | DePauw University 45, Rose-Hulman 16 | Box score |